Hisashi Arase Selected Research

Histocompatibility Antigens Class II

3/2022	Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules.
11/2021	The major histocompatibility complex: new insights from old molecules into the pathogenesis of autoimmunity.
2/2016	[Misfolded proteins complexed with HLA class II molecules are involved in autoimmune diseases as a target for autoantibodies].
1/2016	Rheumatoid Rescue of Misfolded Cellular Proteins by MHC Class II Molecules: A New Hypothesis for Autoimmune Diseases.
1/2016	Misfolded proteins complexed with MHC class II molecules are targets for autoantibodies.
11/2015	Cellular misfolded proteins rescued from degradation by MHC class II molecules are possible targets for autoimmune diseases.

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Hisashi Arase Research Topics

Disease

12	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 01/2014
8	Infections 12/2022 - 05/2003
8	Neoplasms (Cancer) 11/2021 - 03/2004
7	Rheumatoid Arthritis 01/2022 - 03/2014
7	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 01/2022 - 04/2015
5	Inflammation (Inflammations) 01/2018 - 06/2012
4	COVID-19 09/2022 - 01/2021
4	Leukemia 03/2022 - 08/2014
3	Lymphoma (Lymphomas) 01/2021 - 01/2016
3	Malaria 11/2020 - 01/2012
3	Herpes Simplex 12/2017 - 03/2008
3	Virus Diseases (Viral Diseases) 12/2004 - 12/2002
2	Varicella Zoster Virus Infection 12/2022 - 01/2022
2	Myositis (Idiopathic Inflammatory Myopathies) 02/2022 - 01/2022
2	Microscopic Polyangiitis 01/2022 - 10/2017
2	Colitis 01/2018 - 03/2012
2	Hypersensitivity (Allergy) 02/2004 - 03/2003
1	Graves Disease (Basedow Disease) 03/2022
1	Bullous Pemphigoid (Pemphigoid) 02/2022
1	Neuromyelitis Optica (Devic's Disease) 01/2022
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2022
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/2021
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2021
1	Multiple Myeloma 01/2020
1	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/2020
1	Systemic Scleroderma (Systemic Sclerosis) 01/2020
1	Ankylosing Spondylitis 01/2019
1	Vitiligo 01/2019
1	Hemorrhage 01/2018
1	Disease Susceptibility (Diathesis) 10/2017
1	Pneumonia (Pneumonitis) 01/2016
1	Bacterial Infections (Bacterial Infection) 01/2016
1	Burkitt Lymphoma (Burkitt's Lymphoma) 01/2016
1	Hodgkin Disease (Hodgkin's Disease) 01/2016
1	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 01/2016
1	Hemolysis 03/2014

Drug/Important Bio-Agent (IBA)

17	AutoantibodiesIBA 03/2022 - 03/2014
13	Proteins (Proteins, Gene)FDA Link 11/2022 - 11/2015
9	Glycoproteins (Glycoprotein)IBA 12/2022 - 03/2008
9	Immunoglobulins (Immunoglobulin)IBA 11/2021 - 03/2008
7	LigandsIBA 12/2022 - 05/2003
7	AntibodiesIBA 01/2022 - 01/2017
6	Histocompatibility Antigens Class IIIBA 03/2022 - 11/2015
6	Immunoglobulin G (IgG)IBA 02/2022 - 03/2014
5	AutoantigensIBA 01/2019 - 01/2014
4	HLA-DR Antigens (HLA-DR)IBA 02/2022 - 10/2017
4	Peptides (Polypeptides)IBA 01/2022 - 01/2016
4	CytokinesIBA 03/2004 - 12/2002
3	Neutralizing AntibodiesIBA 11/2022 - 01/2021
3	Monoclonal AntibodiesIBA 01/2021 - 01/2016
3	Leukocyte Immunoglobulin-like Receptor B1IBA 11/2020 - 12/2017
2	IntegrinsIBA 02/2022 - 01/2013
2	Immune Checkpoint InhibitorsIBA 01/2020 - 10/2018
2	Heme (Haem)IBA 01/2018 - 03/2014
2	Antiviral Agents (Antivirals)IBA 01/2016 - 10/2010
2	ChemokinesIBA 06/2012 - 03/2003
2	KIR ReceptorsIBA 01/2012 - 01/2007
2	Natural Killer Cell ReceptorsIBA 12/2004 - 03/2004
2	Immunoglobulin E (IgE)IBA 02/2004 - 03/2003
1	Sialic Acid Binding Immunoglobulin-like LectinsIBA 12/2022
1	Myelin-Associated GlycoproteinIBA 12/2022
1	AcidsIBA 11/2022
1	DNA VaccinesIBA 09/2022
1	VaccinesIBA 09/2022
1	Thyrotropin Receptors (Thyrotropin Receptor)IBA 03/2022
1	Aquaporin 4IBA 01/2022
1	HLA-DQA1 antigen (HLA DQA1)IBA 01/2022
1	DNA (Deoxyribonucleic Acid)IBA 01/2022
1	AntigensIBA 01/2022
1	Fc Receptors (Fc Receptor)IBA 01/2022
1	EpitopesIBA 12/2021
1	B-Lymphocyte Epitopes (B-Cell Epitope)IBA 01/2021
1	Fibronectins (Fibronectin)IBA 01/2021
1	Immunoglobulin M (IgM)IBA 01/2021
1	SARS-CoV-2 spike proteinIBA 01/2021
1	Insulin (Novolin)FDA Link 01/2021
1	Blocking AntibodiesIBA 01/2021
1	ProinsulinIBA 01/2021
1	Membrane Proteins (Integral Membrane Proteins)IBA 11/2020
1	HLA-B27 Antigen (HLA B27 Antigen)IBA 01/2019
1	rhododendrolIBA 01/2019
1	Hemoglobins (Hemoglobin)IBA 01/2018
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2018
1	Dextrans (Dextran)FDA Link 01/2018
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2018
1	Peroxidase (Myeloperoxidase)IBA 10/2017
1	Simplexvirus glycoprotein BIBA 01/2016
1	SugarsIBA 01/2016
1	Tumor Viral Antigens (Large T Antigen)IBA 01/2016
1	Complement System Proteins (Complement)IBA 01/2016
1	Peptide Hydrolases (Proteases)FDA Link 01/2016
1	Pharmaceutical PreparationsIBA 01/2016
1	CaspasesIBA 01/2016
1	Dextran SulfateIBA 06/2015
1	Angiopoietin-like ProteinsIBA 08/2014

Therapy/Procedure

1	Transplantation 03/2022
1	Aftercare (After-Treatment) 01/2020
1	Immunotherapy 01/2020
1	Therapeutics 10/2018
1	Intravenous Injections 01/2016